What is the most important information I should know about Naprosyn?

• Take Naprosyn with food, milk, or an antacid to lessen stomach upset.
• Do not crush or chew the extended-release forms of Naprosyn (e.g., Naprelan, EC Naprosyn, others). Swallow them whole. These are specially formulated to release slowly in the body. Ask your pharmacist if you do not know if you have an extended-release formulation.
• Contact your doctor if you experience blood in vomit or bloody, black, or tarry stools. These symptoms could indicate damage to the stomach or intestines, which could be dangerous.
• Many over-the-counter cough, cold, allergy, and pain medicines contain aspirin or other medicines similar to Naprosyn (such as ibuprofen, ketoprofen, and others). Before taking any prescription or over-the-counter medicine, talk to your doctor and pharmacist.
• Patients who are taking over-the-counter Naprosyn products (Aleve) should follow the instructions on the label. Do not exceed the recommended over-the-counter doses for Naprosyn (220 milligrams twice daily) and do not take Naprosyn for longer than ten days unless a physician directs otherwise.
• Avoid alcohol or use it with moderation. If you drink more than three alcoholic beverages a day, Naprosyn may increase the risk of dangerous stomach bleeding. Talk to your doctor before taking Naprosyn if you drink more than 3 alcoholic beverages a day.
• Use caution when driving, operating machinery, or performing other hazardous activities. Naprosyn may cause dizziness. If you experience dizziness, avoid these activities.

What is Naprosyn?

• Naprosyn is in a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Naprosyn works by reducing hormones that cause inflammation and pain in the body.
• Naprosyn is used to reduce pain, inflammation, and stiffness caused by many conditions, such as osteoarthritis, rheumatoid arthritis, gout, ankylosing spondylitis, injury, abdominal cramps associated with menstruation, tendinitis, and bursitis.
• Naprosyn may also be used for purposes other than those listed in this medication guide.

What should I discuss with my healthcare provider before taking Naprosyn?

• Before taking this medication, tell your doctor if you
  • have an allergy to aspirin or any other NSAIDs,
  • have an ulcer or bleeding in your stomach,
  • drink more than three alcoholic beverages a day,
  • have liver disease,
  • have kidney disease,
  • have a coagulation (bleeding) disorder,
  • have congestive heart failure,
  • have fluid retention,
  • have heart disease, or
  • have high blood pressure.
• You may not be able to take Naprosyn, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.
• Naprosyn is in the FDA pregnancy category B. This means that it is not expected to be harmful to an unborn baby. Naprosyn should not be taken late in pregnancy (the third trimester) because a similar drug is known to affect the baby's heart. Do not take Naprosyn without first talking to your doctor if you are pregnant.
• Naprosyn passes into breast milk and may affect a nursing infant. Do not take this medicine without first talking to your doctor if you are breast-feeding a baby.

How should I take Naprosyn?

• Take Naprosyn exactly as directed by your doctor. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you.
• Take each dose with a full glass of water.
• Take Naprosyn with milk, food, or an antacid to lessen stomach upset.
• Do not crush or chew the extended-release forms of Naprosyn (e.g., Naprelan, EC Naprosyn, others). Swallow them whole. These are specially formulated to release slowly in the body. Ask your pharmacist if you do not know if you have an extended-release formulation.
• Patients who are taking over-the-counter Naprosyn products (Aleve) should follow the instructions on the label. Do not exceed the recommended over-the-counter doses for Naprosyn (220 milligrams twice daily) and do not take Naprosyn for longer than ten days unless a physician directs otherwise.
• Shake the suspension well before measuring a dose. To ensure that you get the correct dose, measure the liquid form of Naprosyn with a special dose-measuring spoon or cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist where you can get one.
• Store Naprosyn at room temperature away from moisture and heat.

What happens if I miss a dose?

• If you are taking Naprosyn on a regular schedule, take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and take only the next regularly scheduled dose. Do not take a double dose.
• If you are taking Naprosyn as needed, take the missed dose if it is needed, then wait the recommended or prescribed amount of time before taking another dose.

What happens if I overdose?

• Seek emergency medical attention if an overdose is suspected.
• Symptoms of a Naprosyn overdose may include nausea, vomiting, stomach pain, dizziness, drowsiness, headache, ringing in the ears, blurred vision, seizures, sweating, numbness or tingling, little or no urine production, and slow breathing.

What should I avoid while taking Naprosyn?

• Avoid prolonged exposure to sunlight. Naprosyn may increase the sensitivity of the skin to sunlight. Use a sunscreen and wear protective clothing when exposure to the sun is unavoidable.
• Avoid alcohol or use it with moderation. If you drink more than three alcoholic beverages a day, Naprosyn may increase the risk of dangerous stomach bleeding. Talk to your doctor before taking Naprosyn if you drink more than 3 alcoholic beverages a day.
• Use caution when driving, operating machinery, or performing other hazardous activities. Naprosyn may cause dizziness. If you experience dizziness, avoid these activities.
• Many over-the-counter cough, cold, allergy, and pain medicines contain aspirin or other medicines similar to Naprosyn (such as ibuprofen, ketoprofen, and others). Before taking any prescription or over-the-counter medicine, talk to your doctor and pharmacist.

What are the possible side effects of Naprosyn?

• Contact your doctor if you experience blood in vomit or bloody, black, or tarry stools. These symptoms could indicate damage to the stomach or intestines, which could be dangerous.
• If you experience any of the following serious side effects, stop taking Naprosyn and seek medical treatment or contact your doctor immediately:
  • an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);
  • muscle cramps, numbness, or tingling;
  • ulcers (open sores) in the mouth;
  • rapid weight gain (fluid retention);
  • seizures;
  • decreased hearing or ringing in the ears;
  • yellowing of your skin or eyes (jaundice); or
  • abdominal cramping, heartburn, or indigestion.
• Other, less serious side effects may be more likely to occur. Continue to take Naprosyn and talk to your doctor if you experience
  • dizziness or headache;
  • nausea, diarrhea, or constipation;
  • depression;
  • fatigue or weakness;
  • dry mouth; or
  • irregular menstrual periods.
• Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect Naprosyn?

• Before taking Naprosyn, tell your doctor if you are taking any of the following drugs:
  • aspirin or another salicylate (form of aspirin) such as salsalate (Disalcid), diflunisal (Dolobid), choline salicylate-magnesium salicylate (Trilisate, Tricosal, others), and magnesium salicylate (Doan's, others);
  • another nonsteroidal anti-inflammatory drug (NSAID) such as diclofenac (Cataflam, Voltaren), etodolac (Lodine), fenoprofen (Nalfon), flurbiprofen (Ansaid), ibuprofen (Motrin, Advil, others), indomethacin (Indocin), ketoprofen (Orudis, Orudis KT), ketorolac (Toradol), meloxicam (Mobic), nabumetone (Relafen), oxaprozin (Daypro), piroxicam (Feldene), sulindac (Clinoril), or tolmetin (Tolectin);
  • an over-the-counter cough, cold, allergy, or pain medicine that contains aspirin, ibuprofen, Naprosyn, or ketoprofen;
  • an anticoagulant (blood thinner) such as warfarin (Coumadin);
  • a steroid such as prednisone (Deltasone);
  • insulin or an oral diabetes medicine such as glipizide (Glucotrol), glyburide (Diabeta, Micronase), and others;
  • probenecid (Benemid);
  • lithium (Eskalith, Lithobid, others); or
  • bismuth subsalicylate in drugs such as Pepto-Bismol.
• You may not be able to take Naprosyn, or you may require a dosage adjustment or special monitoring during treatment if you are taking any of the medicines listed above.
• Drugs other than those listed here may also interact with Naprosyn. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including vitamins, minerals, and herbal products.